منابع مشابه
Gut-liver interaction in triglyceride-rich lipoprotein metabolism.
The liver and intestine have complementary and coordinated roles in lipoprotein metabolism. Despite their highly specialized functions, assembly and secretion of triglyceride-rich lipoproteins (TRL; apoB-100-containing VLDL in the liver and apoB-48-containing chylomicrons in the intestine) are regulated by many of the same hormonal, inflammatory, nutritional, and metabolic factors. Furthermore,...
متن کاملHepatic ABCA1 and VLDL triglyceride production.
Elevated plasma triglyceride (TG) and reduced high density lipoprotein (HDL) concentrations are prominent features of metabolic syndrome (MS) and type 2 diabetes (T2D). Individuals with Tangier disease also have elevated plasma TG concentrations and a near absence of HDL, resulting from mutations in ATP binding cassette transporter A1 (ABCA1), which facilitates the efflux of cellular phospholip...
متن کاملChronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats.
We recently observed that ANG II receptor blocker therapy improved the overproduction of triglyceride (TG) in fructose-fed rats and Zucker fatty rats with insulin resistance, which in turn suggests that ANG II may stimulate TG production. Accordingly, we investigated the effects of ANG II on TG production and the association with insulin resistance in normal rats. Male Wistar rats were continuo...
متن کاملEnergy expenditure, insulin, and VLDL-triglyceride production in humans.
Hypertriglyceridemia is considered a cardiovascular risk factor in diabetic and nondiabetic subjects. In this study, we aimed to determine potential regulators of very low density lipoprotein-triglyceride (TG) production. VLDL-TG kinetics were measured in 13 men and 12 women [body mass index [mean (range)]: 24.8 (20.2-35.6) kg/m(2)]. VLDL-TG production was assessed from the plasma decay of a bo...
متن کاملMathematically Modeling the Role of Triglyceride Production on Leptin Resistance
Diet-induced obesity is becoming more common all over the world, which is increasing the prevalence of obesity-induced chronic diseases such as diabetes, coronary heart disease, cancer, and sleep-apnea. Many experimental results show that obesity is often associated with an elevated concentration of plasma leptin and triglycerides. Triglycerides inhibit the passage of leptin across the blood br...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2012
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2011.09.013